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in the g- rich portion of intron 3, secondary dna. analysis of the p53 regulator mdm2 and the identification of the novel p53 target gene lrp1. the first component of this work examined the role p53 plays in mediating apoptosis in response to gamma- radiation during distinct stages of post- natal mammary gland. the second part of this dissertation focused on whether detachment of epithelial cells from their extracellular matrix results in cell death that is p53- dependent or - independent. the tp53 tumor suppressor is the most mutated gene in human cancers. recent studies using genetically modified mouse models have shown that restoring the expression of wild- type p53 has led to tumor growth suppression in various types of tumors lacking p53. other mechanisms, e. upregulation of mdm2 levels, exist in tumors to inactivate the p53 pathway.
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